MEMORIA 2022 - Área 6. Inmunología, Microbiología y Enfermedades Infecciosas

Área 6. Inmunología, Microbiología y Enfermedades Infecciosas

OBJETIVOS CIENTÍFICOS VINCULADOS AL PLAN ESTRATÉGICO

Generar conocimiento científico de excelencia: en el año 2022 se mantienen los buienos resultados del área del año anterior. Los indicadores de liderazgo se mantienen a excepción del factor de impacto acumulado.
Captación de talento científico: notable mejoría en la captación de talento científico con la consecución de 5 ayudas de recursos humanos competitivas. Crecimiento importante en el número de R3 pasando de 15 a 26 investigadores. También se destaca la incorporación de un nuevo grupo emergente que trabaja en Bioingeniería Tisular y Medicina Regenerativa.
Dinamizar la captación de recursos: la captación de recursos ha sido superior a 2021 pero de menor cuantía, alcanzando los 1.4 millones de euros. Destacamos la concesión de dos ayudas europeas. Los ingresos por investigación clínica también han aumentado notablemente siendo el mejor año de la serie histórica.

8 Grupos de Investigación

INMUNOLOGÍA E INMUNOTOLERANCIA EN TRASPLANTES Y ENFERMEDADES DE BASE INMUNOLÓGICA (CONSOLIDADO)
INMUNIDAD, INFLAMACIÓN Y CÁNCER (CONSOLIDADO)
TRASPLANTE HEMATOPOYÉTICO / TERAPIA CELULAR (CONSOLIDADO)
INMUNIDAD INNATA EN LA SALUD Y LA ENFERMEDAD (EMERGENTE)
PATOLOGÍA INFECCIOSA, MICROBIOLOGÍA CLÍNICA Y MEDICINA TROPICAL (EMERGENTE)
ONCOLOGÍA CLÍNICA Y TRASLACIONAL (CLÍNICO ASOCIADO)
AUTOFAGIA, RESPUESTA INMUNE Y TOLERANCIA EN PROCESOS PATOLÓGICOS (EMERGENTE)
BIOINGENIERÍA TISULAR Y MEDICINA REGENERATIVA (EMERGENTE)

INDICADORES GENERALES

Nº Publicaciones

637.45

Impacto Total

6.85

Impacto Medio

Tipo	Nº Pubs	FI total	FI Medio
Originales	79 (84.95%)	568.39	7.19
Revisiones	14 (15.05%)	69.06	4.93

67.74

Q1%

22.58

D1%

FI >= 15

Tipo	Nº Q1	Nº D1	Nº FI >= 15
Originales	53	20	5
Revisiones	10	1	0

INDICADORES DE LIDERAZGO

51 (55.0%)

Nº Publicaciones

324.65

Impacto Total

6.37

Impacto Medio

	Nº Pubs	FI total	FI Medio
Mujer	20 (39.22%)	106.19	5.31
Hombre	31 (60.78%)	218.46	7.05

64.71

Q1%

19.61

D1%

FI >= 15

	Nº Q1	Nº D1	Nº FI >= 15
Mujer	16	5	0
Hombre	17	5	2

OTROS INDICADORES

22.05

HCP10% (2018-2022)

38.1

HCP10 Liderado% (2018-2022)

15.48

HCP10 Lid. Mujeres% (2018-2022)

2.38

Crown (2018-2022)

84.95

Open Access%

33.33

Col. International%

* Se muestran las 5 especies, los 10 genes y las 20 enfermedades más nombradas. Los valores están normalizados logarítmicamente en base al número de publicaciones.

INDICADORES EVOLUTIVOS

DESTACADAS

Roca FJ, Whitworth LJ, Prag HA et al. Tumor necrosis factor induces pathogenic mitochondrial ROS in tuberculosis through reverse electron transport. Science, 2022, 376, eabh2841, PMID: 35737799, FI: 56.9

Orenes-Pinero E, Navas-Carrillo D, Moreno-Docon A, ..., Ramirez P*. Confirmation of SARS-CoV-2 airborne dissemination indoors using "COVID-19 traps". Journal of Infection, 2022, 84, 343-350, PMID: 34953900, FI: 28.2

Garcia-Bernal D, Blanquer M, Martinez CM et al. Enforced mesenchymal stem cell tissue colonization counteracts immunopathology. , 2022, 7, 61, PMID: 36261464, FI: 14.404

Tyrkalska SD, Martinez-Lopez A, Arroyo AB, ..., Cayuela ML*, Mulero V*. Differential proinflammatory activities of Spike proteins of SARS-CoV-2 variants of concern. Science Advances, 2022, 8, eabo0732, PMID: 36112681, FI: 13.6

Pardo-Sanchez I, Garcia-Moreno D*, Mulero V*. Zebrafish Models to Study the Crosstalk between Inflammation and NADPH Oxidase-Derived Oxidative Stress in Melanoma. , 2022, 11, PMID: 35883768, FI: 7.675

LISTADO COMPLETO

Pinana JL, Lopez-Corral L, Martino R, ..., Sanchez-Salinas A et al. SARS-CoV-2 vaccine response and rate of breakthrough infection in patients with hematological disorders. , 2022, 15, 54, PMID: 35526045, FI: 23.168

Fernandez-Sevilla LM, Valencia J, Ortiz-Sanchez P, ..., Martinez-Sanchez MV et al. High BMP4 expression in low/intermediate risk BCP-ALL identifies children with poor outcome. Blood, 2022, blood.2021013506 [pii], PMID: 35313334, FI: 20.3

Sanchez Barrueco A, Mateos-Moreno MV, Martinez-Beneyto Y et al. Effect of oral antiseptics in reducing SARS-CoV-2 infectivity: evidence from a randomized double-blind clinical trial. , 2022, 11, 1833-1842, PMID: 35796097, FI: 19.568

Teil M, Dovero S, Bourdenx M, ..., Estrada C et al. Brain injections of glial cytoplasmic inclusions induce a multiple system atrophy-like pathology. Brain, 2022, 145, 1001-1017, PMID: 35285474, FI: 14.5

Lankester AC, Neven B, Mahlaoui N, ..., Moraleda J et al. Hematopoietic cell transplantation in severe combined immunodeficiency: The SCETIDE 2006-2014 European cohort. Journal of Allergy and Clinical Immunology, 2022, 149, 1744-1754.e8, PMID: 34718043, FI: 14.2

Sojo-Dorado J, Lopez-Hernandez I, Rosso-Fernandez C, ..., Hernandez-Torres A et al. Effectiveness of Fosfomycin for the Treatment of Multidrug-Resistant Escherichia coli Bacteremic Urinary Tract Infections: A Randomized Clinical Trial. Jama Network Open, 2022, 5, e2137277, PMID: 35024838, FI: 13.8

Schlotawa L, Lopez A, Sanchez-Elexpuru G, Tyrkalska SD et al. An inducible expression system for the manipulation of autophagic flux in vivo. Autophagy, 2022, , 1-14, PMID: 36310368, FI: 13.3

Pinana JL, Lopez-Corral L, Martino R, ..., Sanchez-Salinas A et al. SARS-CoV-2-reactive antibody detection after SARS-CoV-2 vaccination in hematopoietic stem cell transplant recipients: Prospective survey from the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group. American Journal of Hematology, 2022, 97, 30-42, PMID: 34695229, FI: 12.8

Garcia-Saenz JA, Martinez-Janez N, Cubedo R, ..., Alonso-Romero JL et al. Sapanisertib plus Fulvestrant in Postmenopausal Women with Estrogen Receptor-Positive/HER2-Negative Advanced Breast Cancer after Progression on Aromatase Inhibitor. Clinical Cancer Research, 2022, 28, 1107-1116, PMID: 34980598, FI: 11.5

Fernandez-Miranda I, Pedrosa L, Llanos M, ..., Marin M et al. Monitoring of circulating tumor DNA predicts response to treatment and early progression in follicular lymphoma: results of a prospective pilot study. Clinical Cancer Research, 2022, CCR-22-1654 [pii], PMID: 36269794, FI: 11.5

Garcia-Sancho AM, Bellei M, Lopez-Parra M, ..., Moraleda JM et al. Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study. Haematologica, 2022, 107, 2675-2684, PMID: 35320921, FI: 10.1

Martin M, Zielinski C, Ruiz-Borrego M, ..., Alonso-Romero JL et al. Overall survival with palbociclib plus endocrine therapy versus capecitabine in postmenopausal patients with hormone receptor-positive, HER2-negative metastatic breast cancer in the PEARL study. European Journal of Cancer, 2022, 168, 12-24, PMID: 35429901, FI: 8.4

Puig N, Contreras MT, Agullo C, ..., Cabanas V et al. Mass spectrometry vs immunofixation for treatment monitoring in multiple myeloma. Blood Advances, 2022, 6, 3234-3239, PMID: 35157768, FI: 7.5

Fernandez-Santos ME, Garcia-Arranz M, Andreu EJ, ..., Moraleda JM et al. Optimization of Mesenchymal Stromal Cell (MSC) Manufacturing Processes for a Better Therapeutic Outcome. Frontiers in Immunology, 2022, 13, 918565, PMID: 35812460, FI: 7.3

Sozio E, Moore NA, Fabris M, ..., Bernal-Morell E et al. Identification of COVID-19 patients at risk of hospital admission and mortality: a European multicentre retrospective analysis of mid-regional pro-adrenomedullin. , 2022, 23, 221, PMID: 36031619, FI: 7.162

Ramos-Muntada M, Trincado JL, Blanco J, ..., Minguela A et al. Clonal heterogeneity and rates of specific chromosome gains are risk predictors in childhood high-hyperdiploid B-cell acute lymphoblastic leukemia. Molecular Oncology, 2022, 10.1002/1878-0261.13276 [doi], PMID: 35726693, FI: 6.6

Toledano-Osorio M, Lopez-Garcia S, Osorio R, ..., Rodriguez-Lozano FJ. Dexamethasone and Doxycycline Doped Nanoparticles Increase the Differentiation Potential of Human Bone Marrow Stem Cells. , 2022, 14, PMID: 36145613, FI: 6.525

Escudero-Ortiz V, Dominguez-Lenero V, Catalan-Latorre A, ..., Sureda M*. Relevance of Therapeutic Drug Monitoring of Tyrosine Kinase Inhibitors in Routine Clinical Practice: A Pilot Study. , 2022, 14, PMID: 35745789, FI: 6.525

Sanz JL, Lopez-Garcia S, Forner L, Rodriguez-Lozano FJ et al. Are Endodontic Solvents Cytotoxic? An In Vitro Study on Human Periodontal Ligament Stem Cells. , 2022, 14, PMID: 36365232, FI: 6.525

Baptista MJ, Tapia G, Munoz-Marmol AM, ..., Moraleda JM et al. Genetic and phenotypic characterisation of HIV-associated aggressive B-cell non-Hodgkin lymphomas, which do not occur specifically in this population: diagnostic and prognostic implications. Histopathology, 2022, 81, 826-840, PMID: 36109172, FI: 6.4

Salinas MD, Valdor R*. Chaperone-Mediated Autophagy in Pericytes: A Key Target for the Development of New Treatments against Glioblastoma Progression. , 2022, 23, PMID: 36012149, FI: 6.208

Ramirez-Pavez T, Garcia-Penaranda A, Garcia-Ibanez P, ..., Martinez-Esparza M*. Potential of Sulforaphane and Broccoli Membrane Vesicles as Regulators of M1/M2 Human Macrophage Activity. , 2022, 23, PMID: 36232440, FI: 6.208

Hernandez-Silva D, Canton-Sandoval J, Martinez-Navarro FJ, ..., Alcaraz-Perez F*, Cayuela ML*. Senescence-Independent Anti-Inflammatory Activity of the Senolytic Drugs Dasatinib, Navitoclax, and Venetoclax in Zebrafish Models of Chronic Inflammation. , 2022, 23, PMID: 36142384, FI: 6.208

Yepes-Molina L, Perez-Jimenez MI, Martinez-Esparza M* et al. Membrane Vesicles for Nanoencapsulated Sulforaphane Increased Their Anti-Inflammatory Role on an In Vitro Human Macrophage Model. , 2022, 23, PMID: 35216054, FI: 6.208

Nunez-Sanchez MA, Martinez-Sanchez MA, Verdejo-Sanchez M, ..., Ramos-Molina B*, ..., Ruiz-Alcaraz AJ*. Anti-Leukemic Activity of Brassica-Derived Bioactive Compounds in HL-60 Myeloid Leukemia Cells. , 2022, 23, PMID: 36362202, FI: 6.208

Legaz I*, Bolarin JM, Campillo JA, ..., Alvarez-Lopez MR. Killer Cell Immunoglobulin-like Receptors (KIR) and Human Leucocyte Antigen C (HLA-C) Increase the Risk of Long-Term Chronic Liver Graft Rejection. , 2022, 23, PMID: 36293011, FI: 6.208

Fatas-Lalana B, Canton-Sandoval J, Rodriguez-Ruiz L, ..., Perez-Oliva AB*, Mulero V*. Impact of Comorbidities of Patients with Psoriasis on Phototherapy Responses. , 2022, 23, PMID: 36076906, FI: 6.208

Garcia-Ayuso D*, Di Pierdomenico J, Garcia-Bernal D, ..., Villegas-Perez MP. Bone marrow-derived mononuclear stem cells in the treatment of retinal degenerations. Neural Regeneration Research, 2022, 17, 1937-1944, PMID: 35142670, FI: 6.1

Gindraux F, Hofmann N, Agudo-Barriuso M, ..., Nicolas FJ*. Perinatal derivatives application: Identifying possibilities for clinical use. Frontiers in Bioengineering and Biotechnology, 2022, 10, 977590, PMID: 36304904, FI: 5.7

Flores AI, Pipino C, Jerman UD, Liarte S et al. Perinatal derivatives: How to best characterize their multimodal functions in vitro. Part C: Inflammation, angiogenesis, and wound healing. Frontiers in Bioengineering and Biotechnology, 2022, 10, 965006, PMID: 35992360, FI: 5.7

Pipino C, Bernabe-Garcia A, Cappellacci I, ..., Nicolas FJ*. Effect of the Human Amniotic Membrane on the Umbilical Vein Endothelial Cells of Gestational Diabetic Mothers: New Insight on Inflammation and Angiogenesis. Frontiers in Bioengineering and Biotechnology, 2022, 10, 854845, PMID: 35866032, FI: 5.7

Del Pozo-Valero M, Corton M, Lopez-Rodriguez R, ..., Perez-Tomas ME et al. Age-dependent association of clonal hematopoiesis with COVID-19 mortality in patients over 60 years. Geroscience, 2022, , 1-11, PMID: 36184726, FI: 5.6

Molina ML, Garcia-Bernal D, Salinas MD, ..., Valdor R*. Chaperone-Mediated Autophagy Ablation in Pericytes Reveals New Glioblastoma Prognostic Markers and Efficient Treatment Against Tumor Progression. Frontiers in Cell and Developmental Biology, 2022, 10, 797945, PMID: 35419364, FI: 5.5

Nanda SK, Vollmer S, Perez-Oliva AB*. Posttranslational Regulation of Inflammasomes, Its Potential as Biomarkers and in the Identification of Novel Drugs Targets. Frontiers in Cell and Developmental Biology, 2022, 10, 887533, PMID: 35800898, FI: 5.5

Aguado de la Rosa C, Cruz Castellanos P, Lazaro-Quintela M, ..., Alonso Romero JL et al. Identification of ALK-positive patients with advanced NSCLC and real-world clinical experience with crizotinib in Spain (IDEALK study). Lung Cancer, 2022, 173, 83-93, PMID: 36162227, FI: 5.3

Torres-Fernandez D, Jimenez de Ory S, Fortuny C, ..., Bernal E et al. Integrase inhibitors in children and adolescents: clinical use and resistance. Journal of Antimicrobial Chemotherapy, 2022, 77, 2784-2792, PMID: 35971971, FI: 5.2

Sanchez-Villalobos M, Blanquer M, Moraleda JM, ..., Salido EJ*, Perez-Oliva AB*. New Insights Into Pathophysiology of beta-Thalassemia. , 2022, 9, 880752, PMID: 35492364, FI: 5.058

Sanz JL, Lopez-Garcia S, Rodriguez-Lozano FJ* et al. Cytocompatibility and bioactive potential of AH Plus Bioceramic Sealer: An in vitro study. International Endodontic Journal, 2022, 55, 1066-1080, PMID: 35950780, FI: 5.0

Alvarez-Zaballos S, Gonzalez-Ramallo V, Quintana E, ..., Garcia-Vazquez E et al. Multivalvular Endocarditis: A Rare Condition with Poor Prognosis. , 2022, 11, PMID: 36012974, FI: 4.964

Alfaro R, Lorente S, Jimenez-Coll V, ..., Muro M*. Evaluating the Link between BAFF System Gene Expression and Acute Rejection Development in Kidney Transplantation. , 2022, 11, PMID: 35887720, FI: 4.964

Iaculli F, Rodriguez-Lozano FJ, Briseno-Marroquin B et al. Vital Pulp Therapy of Permanent Teeth with Reversible or Irreversible Pulpitis: An Overview of the Literature. , 2022, 11, PMID: 35887779, FI: 4.964

Wangensteen R, Gomez-Guzman M, Banegas I, ..., Garcia-Estan J et al. Vasoconstrictor and Pressor Effects of Des-Aspartate-Angiotensin I in Rat. , 2022, 10, PMID: 35740253, FI: 4.757

Campos-Sanchez JC, Carrillo NG, Guardiola FA, ..., Esteban MA. Ultrasonography and X-ray micro-computed tomography characterization of the effects caused by carrageenin in the muscle of gilthead seabream (Sparus aurata). Fish & Shellfish Immunology, 2022, 123, 431-441, PMID: 35337979, FI: 4.7

Mata-Molanes JJ, Rebollo-Liceaga J, Martinez-Navarro EM, ..., Sureda M*. Relevance of Fc Gamma Receptor Polymorphisms in Cancer Therapy With Monoclonal Antibodies. Frontiers in Oncology, 2022, 12, 926289, PMID: 35814459, FI: 4.7

Pecci-Lloret MR, Pecci-Lloret MP, Rodriguez-Lozano FJ. Special Care Patients and Caries Prevalence in Permanent Dentition: A Systematic Review. , 2022, 19, PMID: 36429911, FI: 4.614

Pecci-Lloret MP, Lopez-Garcia S, Rodriguez-Lozano FJ, ..., Garcia-Bernal D. In Vitro Biocompatibility of Several Children's Toothpastes on Human Gingival Fibroblasts. , 2022, 19, PMID: 35270647, FI: 4.614

Janjua OS, Qureshi SM, Shaikh MS, ..., Rodriguez-Lozano FJ et al. Autogenous Tooth Bone Grafts for Repair and Regeneration of Maxillofacial Defects: A Narrative Review. , 2022, 19, PMID: 35329377, FI: 4.614

Munoz-Prieto A, Rubic I, Gonzalez-Sanchez JC, ..., Bernal E et al. Saliva changes in composition associated to COVID-19: a preliminary study. Scientific Reports, 2022, 12, 10879, PMID: 35760827, FI: 4.6

Stelling-Ferez J, Gabaldon JA, Nicolas FJ*. Oleanolic acid stimulation of cell migration involves a biphasic signaling mechanism. Scientific Reports, 2022, 12, 15065, PMID: 36064555, FI: 4.6

Di Chiacchio IM, Gomez-Abenza E, Paiva IM, ..., Mulero V*. Bee pollen in zebrafish diet affects intestinal microbiota composition and skin cutaneous melanoma development. Scientific Reports, 2022, 12, 9998, PMID: 35705722, FI: 4.6

Lopez-Rodriguez R, Del Pozo-Valero M, Corton M, ..., Perez-Tomas ME et al. Presence of rare potential pathogenic variants in subjects under 65 years old with very severe or fatal COVID-19. Scientific Reports, 2022, 12, 10369, PMID: 35725860, FI: 4.6

Rodriguez-Lozano FJ*, Lopez-Garcia S, Sanchez-Bautista S et al. Effect of milled and lithography-based additively manufactured zirconia (3Y-TZP) on the biological properties of human osteoblasts. Journal of Prosthetic Dentistry, 2022, S0022-3913(22)00074-9 [pii], PMID: 35264309, FI: 4.6

Ros-Lucas JA, Pascual-Figal DA, Noguera-Velasco JA et al. CA 15-3 prognostic biomarker in SARS-CoV-2 pneumonia. Scientific Reports, 2022, 12, 6738, PMID: 35469047, FI: 4.6

Bueno C*, Blanquer M, Garcia-Bernal D, ..., Moraleda JM. Binucleated human bone marrow-derived mesenchymal cells can be formed during neural-like differentiation with independence of any cell fusion events. Scientific Reports, 2022, 12, 20615, PMID: 36450873, FI: 4.6

Garcia-Alvarez L, Garcia-Garcia C, Munoz P, ..., Garcia-Vazquez E et al. Bartonella Endocarditis in Spain: Case Reports of 21 Cases. , 2022, 11, PMID: 35631082, FI: 4.531

Guerrero-Girones J, Lopez-Garcia S, Pecci-Lloret MR, ..., Garcia-Bernal D. In vitro biocompatibility testing of 3D printing and conventional resins for occlusal devices. Journal of Dentistry, 2022, 123, 104163, PMID: 35577252, FI: 4.4

Mazagatos C, Delgado-Sanz C, Monge S et al. COLABORADORES: ..., Moreno Docon A et al. COVID-19 vaccine effectiveness against hospitalization due to SARS-CoV-2: A test-negative design study based on Severe Acute Respiratory Infection (SARI) sentinel surveillance in Spain. Influenza and Other Respiratory Viruses, 2022, 10.1111/irv.13026 [doi], PMID: 35880469, FI: 4.4

Garcia-Galan A, Baranowski E, Hygonenq MC, ..., De la Fe C et al. Genome Mosaicism in Field Strains of Mycoplasma bovis as Footprints of In-Host Horizontal Chromosomal Transfer. Applied and Environmental Microbiology, 2022, 88, e0166121, PMID: 34669423, FI: 4.4

Parrado A*, Rubio G, Serrano M, ..., Hernandez-Caselles T*. Dissecting the transcriptional program of phosphomannomutase 2-deficient cells: Lymphoblastoide B cell lines as a valuable model for congenital disorders of glycosylation studies. Glycobiology, 2022, 32, 84-100, PMID: 34420056, FI: 4.3

Bernal E*, Martinez M, Campillo JA, ..., Minguela A*. Moderate to Intense Physical Activity Is Associated With Improved Clinical, CD4/CD8 Ratio, and Immune Activation Status in HIV-Infected Patients on ART. Open Forum Infectious Diseases, 2022, 9, ofab654, PMID: 35146043, FI: 4.2

Galecio JS, Escudero E, Corrales JC, ..., Marin P. Susceptibility of caprine mastitis pathogens to tildipirosin, gamithromycin, oxytetracycline, and danofloxacin: effect of serum on the in vitro potency of current macrolides. World Journal of Microbiology & Biotechnology, 2022, 38, 221, PMID: 36097302, FI: 4.1

Javaloyes N, Crespo A, Redal MC, ..., Sureda M*. Psycho-Oncological Intervention Through Counseling in Patients With Differentiated Thyroid Cancer in Treatment With Radioiodine (COUNTHY, NCT05054634): A Non-randomized Controlled Study. Frontiers in Psychology, 2022, 13, 767093, PMID: 35282223, FI: 3.8

Garcia-Bernal D, Pecci-Lloret MP, Lopez-Garcia S. The Cytocompatibility of Silver Diamine Fluoride on Mesenchymal Stromal Cells from Human Exfoliated Deciduous Teeth: An In Vitro Study. , 2022, 15, PMID: 35329556, FI: 3.748

Kumar N, Maher N, Amin F, ..., Rodriguez-Lozano FJ et al. Biomimetic Approaches in Clinical Endodontics. , 2022, 7, PMID: 36546929, FI: 3.743

Antonio CCP, Alida GG, Elena GG, ..., Jose GM. Cytoreductive Surgery With or Without HIPEC After Neoadjuvant Chemotherapy in Ovarian Cancer: A Phase 3 Clinical Trial. Annals of Surgical Oncology, 2022, 29, 2617-2625, PMID: 34812982, FI: 3.7

Rodriguez-Lozano FJ*, Lozano A, Lopez-Garcia S et al. Biomineralization potential and biological properties of a new tantalum oxide (Ta2O5)-containing calcium silicate cement. Clinical Oral Investigations, 2022, 26, 1427-1441, PMID: 34382106, FI: 3.606

Vicent L, Goenaga MA, Munoz P, ..., Garcia-Vazquez E et al. Infective endocarditis in children and adolescents: a different profile with clinical implications. Pediatric Research, 2022, 10.1038/s41390-022-01959-3 [doi], PMID: 35149848, FI: 3.6

Di Pierdomenico J, Gallego-Ortega A, Martinez-Vacas A, ..., Garcia-Ayuso D*. Intravitreal and subretinal syngeneic bone marrow mononuclear stem cell transplantation improves photoreceptor survival but does not ameliorate retinal function in two rat models of retinal degeneration. Acta Ophthalmologica, 2022, 10.1111/aos.15165 [doi], PMID: 35514078, FI: 3.4

Martinez DAS*, Quilez-Cutillas A, Jimenez-Labaig P et al. Current professional standing of young medical oncologists in Spain: a nationwide survey by the Spanish Society of Medical Oncology + MIR section. Clinical & Translational Oncology, 2022, , 1-7, PMID: 36418642, FI: 3.4

Atucha NM*, Romecin P, Vargas F, Garcia-Estan J*. Effects of Flavonoids in Experimental Models of Arterial Hypertension. Current Topics in Medicinal Chemistry, 2022, 22, 735-745, PMID: 34749613, FI: 3.4

Lozano-Guillen A, Lopez-Garcia S, Rodriguez-Lozano FJ et al. Comparative cytocompatibility of the new calcium silicate-based cement NeoPutty versus NeoMTA Plus and MTA on human dental pulp cells: an in vitro study. Clinical Oral Investigations, 2022, 26, 7219-7228, PMID: 36053352, FI: 3.4

Kiyak YS, Budakoglu II, Garcia-Estan J et al. What do Turkish, Spanish, and Pakistani medical students value in specialty training positions? A discrete choice experiment. , 2022, 22, 752, PMID: 36320062, FI: 3.263

Alfaro R, Llorente S, Martinez P, ..., Muro M*. Monitoring of Soluble Forms of BAFF System (BAFF, APRIL, sR-BAFF, sTACI and sBCMA) in Kidney Transplantation. Archivum Immunologiae et Therapiae Experimentalis, 2022, 70, 21, PMID: 36136146, FI: 3.2

Fernandez S, Moreno-Castano AB, Palomo M, ..., Garcia-Bernal D et al. Distinctive Biomarker Features in the Endotheliopathy of COVID-19 and Septic Syndromes. Shock, 2022, 57, 95-105, PMID: 34172614, FI: 3.1

Mery A, Jawhara S, Francois N, ..., Martinez-Esparza M et al. Identification of fungal trehalose for the diagnosis of invasive candidiasis by mass spectrometry. Biochimica et Biophysica Acta-General Subjects, 2022, 1866, 130083, PMID: 35033574, FI: 3.0

Lopez-Guillermo A, Canales MA, Dlouhy I, ..., Moraleda JM* et al. A randomized phase II study comparing consolidation with a single dose of (90)Y ibritumomab tiuxetan vs. maintenance with rituximab for two years in patients with newly diagnosed follicular lymphoma responding to R-CHOP. Long-term follow-up results. , 2022, 63, 93-100, PMID: 34459702, FI: 2.996

Sanchez Martinez DA*, Salas-Lucia F, Jiang H, ..., Alonso Romero JL*. Drug cost avoidance analysis of cancer clinical trials in Spain: a study on cost contributors and their impact. , 2022, 22, 948, PMID: 35883128, FI: 2.908

Lozano-Gil JM, Rodriguez-Ruiz L, Tyrkalska SD, ..., Perez-Oliva AB*, Mulero V*. Gasdermin E mediates pyroptotic cell death of neutrophils and macrophages in a zebrafish model of chronic skin inflammation. Developmental and Comparative Immunology, 2022, 132, 104404, PMID: 35341794, FI: 2.9

Gomez-Abellan V, Perez-Oliva AB, Cabas I, ..., Mulero V*. Peroxisome proliferator-activated receptors alpha and beta mediate the anti-inflammatory effects of the cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-PGJ(2) in fish granulocytes. Developmental and Comparative Immunology, 2022, 136, 104498, PMID: 35948178, FI: 2.9

Martinez-Gascon LE*, Ortiz MC*, Galindo M, ..., Rodriguez F*. Role of heme oxygenase in the regulation of the renal hemodynamics in a model of sex-dependent programmed hypertension by maternal diabetes. American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 2022, 322, R181-R191, PMID: 34984919, FI: 2.8

Salas-Coronas J, Perez Perez A, Roure S, ..., Garcia Vazquez E et al. [Consensus document for the management of schistosomiasis in Primary Care]. Atencion Primaria, 2022, 54, 102408, PMID: 35753207, FI: 2.5

Campos-Sanchez JC, Vitarelli E, Guardiola FA, ..., Esteban MA*. Implication of mucus-secreting cells, acidophilic granulocytes and monocytes/macrophages in the resolution of skin inflammation caused by subcutaneous injection of lambda/kappa-carrageenin to gilthead seabream (Sparus aurata) specimens. Journal of Fish Diseases, 2022, 45, 19-33, PMID: 34549432, FI: 2.5

Pecci-Lloret MP, Nandin-Muttoni G, Pecci-Lloret MR, ..., Rodriguez-Lozano FJ. Scaffolds for pulp revitalisation: A systematic review of randomized clinical trials. Annals of Anatomy-Anatomischer Anzeiger, 2022, 243, 151936, PMID: 35367348, FI: 2.2

Guerrero-Girones J, Lopez-Garcia S, Pecci-Lloret MR, ..., Garcia-Bernal D. Influence of dual-cure and self-cure abutment cements for crown implants on human gingival fibroblasts biological properties. Annals of Anatomy-Anatomischer Anzeiger, 2022, 239, 151829, PMID: 34500053, FI: 2.2

Torres-Cantero AM, Alvarez Leon EE, Moran-Sanchez I et al. [Health impact of COVID pandemic. SESPAS Report 2022]. Gaceta Sanitaria, 2022, 36 Suppl 1, S4-S12, PMID: 35781147, FI: 1.9

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AYUDAS CONCEDIDAS EN 2022

TOTAL DE AYUDAS CONCEDIDAS

Nº Ayudas

1.38M €

Financiación

TOTAL DE AYUDAS RECURSOS HUMANOS CONCEDIDAS

Nº Ayudas

0.36M €

Financiación

TOTAL DE AYUDAS PROYECTOS I+D+i CONCEDIDAS

Nº Ayudas Europeas

0.35M €

Financiación Europea

Nº Ayudas Nacionales

0.35M €

Financiación Nacional

Nº Ayudas Regionales

0.33M €

Financiación Regional

TOTAL DE REDES CONCEDIDAS

Nº Ayudas

0.0M €

Financiación

OTRAS AYUDAS COMPETITIVAS CONCEDIDAS (MOVILIDAD, ORGANIZACIÓN DE EVENTOS CIENTÍFICOS, ...)

Nº Ayudas

0.0K €

Financiación

PROYECTOS DE I+D+i Y AYUDAS DE RRHH ACTIVAS EN 2022

TOTAL AYUDAS

RECURSOS HUMANOS

REDES

PROYECTOS INTERNACIONALES

PROYECTOS NACIONALES

PROYECTOS REGIONALES

INICIADA EN 2022

Nº Estudios

Nº Ensayos Clínicos

Nº Producto Sanitario

Nº Estudios Post-Autorización

Nº Otros Estudios

ACTIVOS EN 2022

237

Nº Estudios

151

Nº Ensayos Clínicos

Nº Producto Sanitario

Nº Estudios Post-Autorización

Nº Otros Estudios

FACTURACIÓN EN 2022

1.32M €

Facturado

Nº Tesis (2 con mención internacional)